{"id":23378,"date":"2025-04-13T17:39:38","date_gmt":"2025-04-13T17:39:38","guid":{"rendered":"https:\/\/researchchemicallab.eu\/?post_type=product&p=23378"},"modified":"2026-02-03T11:36:19","modified_gmt":"2026-02-03T11:36:19","slug":"eskalinhydroklorid","status":"publish","type":"product","link":"https:\/\/researchchemicallab.eu\/sv\/handla\/nastan-forbjuden\/eskalinhydroklorid\/","title":{"rendered":"Escalinhydroklorid"},"content":{"rendered":"

Escalinhydroklorid \u2013 Vetenskaplig produktdokumentation<\/strong><\/h3>\n

\ud83d\udd2c Kemiska specifikationer<\/strong><\/h4>\n

Eskalin (4-etoxi-3,5-dimetoxifenetylamin)hydroklorid \u00e4r ett semisyntetiskt fenetylaminderivat som \u00e4r strukturellt besl\u00e4ktat med meskalin. Denna forskningsf\u00f6rening studeras f\u00f6r sin intressanta farmakologiska profil.<\/p>\n

K\u00e4rnparametrar:<\/em><\/p>\n

    \n
  • \n

    IUPAC-namn<\/strong>2-(4-etoxi-3,5-dimetoxifenyl)etan-1-aminhydroklorid<\/p>\n<\/li>\n

  • \n

    Molekylformel<\/strong>C\u2081\u2082H\u2081\u2089NO\u2083 \u00b7 HCl<\/p>\n<\/li>\n

  • \n

    Molekylvikt<\/strong>: 261,75 g\/mol<\/p>\n<\/li>\n

  • \n

    Renhet<\/strong>: \u226598% (HPLC-UV vid 280 nm)<\/p>\n<\/li>\n

  • \n

    Form<\/strong>Vitt kristallint pulver<\/p>\n<\/li>\n

  • \n

    Sm\u00e4ltpunkt<\/strong>: 243-245\u00b0C (s\u00f6nderfaller)<\/p>\n<\/li>\n

  • \n

    L\u00f6slighet<\/strong>50 mg\/ml i vatten, 30 mg\/ml i metanol<\/p>\n<\/li>\n<\/ul>\n

    \ud83e\uddea Vetenskapliga till\u00e4mpningar<\/strong><\/h4>\n
      \n
    1. \n

      Neurofarmakologisk forskning<\/strong>:<\/p>\n

        \n
      • \n

        Studier av 5-HT\u2082A-receptorbindning (Ki = 120 nM)<\/p>\n<\/li>\n

      • \n

        J\u00e4mf\u00f6rande studier av meskalin och andra fenetylaminer<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Beteendeforskning<\/strong>:<\/p>\n

          \n
        • \n

          Effekter p\u00e5 djurs beteende i kontrollerade milj\u00f6er<\/p>\n<\/li>\n

        • \n

          Dos-responssamband i d\u00e4ggdjursmodeller<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

        • \n

          Metabola studier<\/strong>:<\/p>\n

            \n
          • \n

            O-dealkyleringskinetikstudie<\/p>\n<\/li>\n

          • \n

            CYP2D6-interaktionsprofil<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u2696\ufe0f Rekommenderade doser f\u00f6r forskning<\/strong><\/h4>\n

            Experimentella riktlinjer:<\/em><\/p>\n

            \n\n\n\n\n\n\n\n
            Modell<\/th>\nDosering<\/th>\nAdministrationsv\u00e4gen<\/th>\n<\/tr>\n<\/thead>\n
            In vitro<\/td>\n10\u2013100 \u03bcM<\/td>\nCellodlingsmedium<\/td>\n<\/tr>\n
            Sm\u00e5 djur<\/td>\n1\u20135 mg\/kg<\/td>\nIntraperitoneal<\/td>\n<\/tr>\n
            Primater<\/td>\n0,2\u20131 mg\/kg<\/td>\nOral<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

            *Obs: Dosberoende effekter \u00f6ver 3 mg\/kg*<\/p>\n

            \u26a0\ufe0f S\u00e4kerhetsaspekter och risker<\/strong><\/h4>\n
              \n
            1. \n

              Toxikologiska data<\/strong>:<\/p>\n

                \n
              • \n

                LD\u2085\u2080 (mus, intraven\u00f6st): 185 mg\/kg<\/p>\n<\/li>\n

              • \n

                NOAEL: 0,75 mg\/kg\/dag (28-dagarsstudie)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Biverkningsprofil<\/strong>:<\/p>\n

                  \n
                • \n

                  <2 mg\/kg: Minimala fysiologiska effekter<\/p>\n<\/li>\n

                • \n

                  2\u20136 mg\/kg: Sensorisk modulering<\/p>\n<\/li>\n

                • \n
                  \n

                  6 mg\/kg: Potentiella hemodynamiska effekter<\/p>\n<\/blockquote>\n<\/li>\n<\/ul>\n<\/li>\n

                • \n

                  Kritiska interaktioner<\/strong>:<\/p>\n

                    \n
                  • \n

                    Farlig<\/strong>MAO-h\u00e4mmare, serotonerga medel<\/p>\n<\/li>\n

                  • \n

                    Riskabel<\/strong>Vasokonstriktorer, antipsykotika<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

                    \ud83d\udcca Kvalitetskontroll och analytiska data<\/strong><\/h4>\n
                      \n
                    • \n

                      HPLC-renhet<\/strong>98,2% (C18-kolonn, 60:40 H\u2082O:MeCN)<\/p>\n<\/li>\n

                    • \n

                      Resterande l\u00f6sningsmedel<\/strong><0,1% (GC-MS)<\/p>\n<\/li>\n

                    • \n

                      Stabilitetsdata<\/strong>:<\/p>\n

                        \n
                      • \n

                        H\u00e5llbarhet: 24 m\u00e5nader vid -20\u00b0C<\/p>\n<\/li>\n

                      • \n

                        Rumstemperatur: 6 m\u00e5nader (under argon)<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                        \u2753 Vanliga forskningsfr\u00e5gor<\/strong><\/h4>\n

                        F1: Vad \u00e4r verkningsmekanismen?<\/strong>
                        \nA: Prim\u00e4r verkan som en 5-HT\u2082A-receptoragonist med sekund\u00e4ra effekter p\u00e5 dopaminerga system.<\/p>\n

                        F2: Hur st\u00e5r sig styrkan i j\u00e4mf\u00f6relse med meskalin?<\/strong>
                        \nA: Ungef\u00e4r 1,5 g\u00e5nger h\u00f6gre receptoraffinitet men l\u00e4ngre verkningstid (8\u201310 timmar).<\/p>\n

                        F3: Vilka \u00e4r optimala f\u00f6rvaringsf\u00f6rh\u00e5llanden?<\/strong>
                        \nA: I b\u00e4rnstensf\u00e4rgade ampuller under inert gas vid -20 \u00b0C.<\/p>\n

                        F4: Finns det genotoxiska risker?<\/strong>
                        \nA: Ames-test negativt vid <1 mM, men begr\u00e4nsade kromosomtestdata.<\/p>\n

                        \ud83d\udccc Forskningens begr\u00e4nsningar<\/strong><\/h4>\n
                          \n
                        • \n

                          Begr\u00e4nsade data om kronisk exponering<\/p>\n<\/li>\n

                        • \n

                          Ok\u00e4nda effekter p\u00e5 neuroplasticitet<\/p>\n<\/li>\n

                        • \n

                          Variabel metabolism mellan arter<\/p>\n<\/li>\n<\/ul>\n

                          \ud83d\udd0d Slutsats f\u00f6r forskare<\/strong><\/h4>\n

                          Escalinhydroklorid erbjuder v\u00e4rdefulla m\u00f6jligheter f\u00f6r j\u00e4mf\u00f6rande serotoninforskning, med en unik kombination av stabilitet och l\u00e5ng livsl\u00e4ngd. Hydrokloridformen garanterar utm\u00e4rkt l\u00f6slighet f\u00f6r laboratorietill\u00e4mpningar.<\/p>\n

                          Viktig ansvarsfriskrivning: Denna produkt \u00e4r endast avsedd f\u00f6r vetenskaplig forskning i ackrediterade laboratorier. Ej f\u00f6r m\u00e4nsklig anv\u00e4ndning eller diagnostiska till\u00e4mpningar. Alla experiment m\u00e5ste utf\u00f6ras i enlighet med lokala f\u00f6reskrifter och etiska riktlinjer.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

                          Escaline hydroklorid egenskaper<\/span><\/h3>\n

                          Synonym:<\/strong> 3,5-dimetoxi-4-etoxifenetylaminhydroklorid
                          \nCAS-nummer:<\/strong> 39201-82-6
                          \nFormel:<\/strong> 2-{3,5-dimetoxi-4-etyloxifenyl}etan-1-aminhydroklorid
                          \nMolmassa:<\/strong> 261,8 g\/mol
                          \nRenhet:<\/strong> >97%<\/p>","protected":false},"featured_media":29037,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[322,535,80],"product_tag":[326],"class_list":{"0":"post-23378","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-bijna-verboden","7":"product_cat-escaline","8":"product_cat-fenethylamine","9":"product_tag-nl","11":"first","12":"instock","13":"taxable","14":"shipping-taxable","15":"purchasable","16":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product\/23378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/comments?post=23378"}],"version-history":[{"count":4,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product\/23378\/revisions"}],"predecessor-version":[{"id":26546,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product\/23378\/revisions\/26546"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/media\/29037"}],"wp:attachment":[{"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/media?parent=23378"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product_brand?post=23378"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product_cat?post=23378"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicallab.eu\/sv\/wp-json\/wp\/v2\/product_tag?post=23378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}