5-MeO-DMT hydrochloride

5-MeO-DMT Hydrochloride – Scientific Product Documentation

General Description

5-MeO-DMT hydrochloride (5-Methoxy-N,N-dimethyltryptamine HCl) is a water-soluble salt of classical tryptamine, particularly suitable for pharmacological research due to its increased stability and bioavailability compared to the freebase form.

Technical Specifications

Scientific Applications

1. Neuropharmacology & Behavioral Research

• Serotonin receptor studies:  Potent 5-HT₁ₐ/₂ₐ agonist with rapid cerebral penetration.

• Animal experiments (in vivo):  Behavioural paradigms (e.g. head-twitch response in rodents).

• Electrophysiology:  Effects on neuronal oscillations (e.g., gamma-band activity).

2. Biochemical & Molecular Studies

• Intracellular signaling:  cAMP accumulation and β-arrestin recruitment assays.

• Enzyme kinetics:  MAO-A metabolism (IC₅₀ ~2-5 μM).

3. Clinically Relevant Research

• Dose-response relationships:  Preclinical safety profiling.

• Comparative pharmacology:  Towards psilocybin, DMT, and other tryptamines.

Experimental Guidelines

Recommended Concentrations

Safety measures

• Personal protection:  Lab coat, gloves (nitrile), safety glasses.

• Handling:  Hygroscopic – close promptly after use.

• Storage:  Airtight, under argon, at -20°C (prevent hydrolysis).

Stability & Storage

• Shelf life:

  • -20°C:  >2 years (unchanged purity).

  • 4°C:  6 months (in dry environment).

• Relegation:

  • Hydrolysis on prolonged exposure to moisture (monitor by HPLC).

Analytical Validation

Each batch comes with:

1. HPLC-UV chromatogram  (C18 column, retention time ~6.2 min).

2. MS/MS fragmentation  (characteristic ions: m/z 219 → 174, 160).

3. Residual solvents  (meet ICH Q3C guidelines).

Legal Status (Netherlands/EU)

• Narcotics legislation:  Not explicitly mentioned in the Opium Act, but possibly under analogous legislation (Appendix II).

• Scientific use:  Permit required for institutions (CCMO approval for animal testing).

• Export control:  Subject to EU Regulation 2019/1998 (psychotropic substances).

Frequently Asked Questions (FAQ)

Q1 : What are the advantages of HCl over freebase?

• Improved solubility  (ideal for injection studies).

• Longer shelf stability  at room temperature.

Q2: Is 5-MeO-DMT-HCl detectable in drug tests?
A: Yes, via:

• LC-MS/MS  (recognized as 5-MeO-DMT + HCl adduct).

• Immunoassays:  Cross-reactivity with DMT (~15-20%).

Q3: Are there risks when combining with MAO inhibitors?
A:  Absolutely.

• Increased risk of  serotonin syndrome  (avoid combination!).

• Use only in MAO-free models.

Q4: How to dispose of waste?
A:

1. Neutralize with  sodium bicarbonate  (pH 7-8).

2. Adsorb with  activated carbon .

3. Dispose of as  hazardous chemical waste  (UN 3249, Class 6.1).

References & Contact

Core literature:

1. Shen et al. (2010). “Pharmacology of 5-MeO-DMT derivatives”.  J Psychopharmacol .

2. Kaasik et al. (2021). “Metabolic pathways of 5-MeO-DMT”.  Xenobiotics .

This product is intended only for authorized scientific research. Not for human consumption or diagnostic use. Please observe local regulations.