{"id":23504,"date":"2025-04-13T17:39:53","date_gmt":"2025-04-13T17:39:53","guid":{"rendered":"https:\/\/researchchemicallab.eu\/?post_type=product&p=23504"},"modified":"2026-02-03T10:35:36","modified_gmt":"2026-02-03T10:35:36","slug":"5-meo-dmt-hydroklorid","status":"publish","type":"product","link":"https:\/\/researchchemicallab.eu\/nb\/butikk\/kjop-5-meo-dmt\/5-meo-dmt-hydroklorid\/","title":{"rendered":"5-MeO-DMT hydroklorid"},"content":{"rendered":"

5-MeO-DMT-hydroklorid \u2013 Vitenskapelig produktdokumentasjon<\/span><\/span><\/strong><\/h3>\n

Generell beskrivelse<\/span><\/span><\/strong><\/h4>\n

5-MeO-DMT-hydroklorid (5-metoksy-N,N-dimetyltryptamin-HCl) er et vannl\u00f8selig salt av klassisk tryptamin, spesielt egnet for farmakologisk forskning p\u00e5 grunn av dets \u00f8kte stabilitet og biotilgjengelighet sammenlignet med den frie baseformen.<\/span><\/span><\/p>\n

\n

Tekniske spesifikasjoner<\/span><\/span><\/strong><\/h3>\n
\n\n\n\n\n\n\n\n\n\n\n\n
Parameter<\/span><\/span><\/strong><\/th>\nSpesifikasjon<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
Kjemisk formel<\/span><\/span><\/strong><\/td>\nC\u2081\u2083H\u2081\u2088N\u2082O \u00b7 HCl<\/span><\/span><\/td>\n<\/tr>\n
Molekylvekt<\/span><\/span><\/strong><\/td>\n254,75 g\/mol<\/span><\/span><\/td>\n<\/tr>\n
Renhet<\/span><\/span><\/strong><\/td>\n\u226598% (analysert med HPLC-UV)<\/span><\/span><\/td>\n<\/tr>\n
Utseende<\/span><\/span><\/strong><\/td>\nHvitt til lysegult krystallinsk pulver<\/span><\/span><\/td>\n<\/tr>\n
L\u00f8selighet<\/span><\/span><\/strong><\/td>\nH\u00f8yt innhold av vann (>50 mg\/ml), metanol, PBS<\/span><\/span><\/td>\n<\/tr>\n
Smeltepunkt<\/span><\/span><\/strong><\/td>\n243\u2013247 \u00b0C (dekomponerer)<\/span><\/span><\/td>\n<\/tr>\n
Stabilitet<\/span><\/span><\/strong><\/td>\nHygroskopisk; oppbevares t\u00f8rt<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

Vitenskapelige anvendelser<\/span><\/span><\/strong><\/h3>\n

1. Nevrofarmakologi og atferdsforskning<\/span><\/span><\/strong><\/h4>\n
    \n
  • \n

    Serotoninreseptorstudier:<\/span><\/span><\/strong> \u00a0Potent 5-HT\u2081\u2090\/\u2082\u2090-agonist med rask cerebral penetrasjon.<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Dyrefors\u00f8k (in vivo):<\/span><\/span><\/strong> \u00a0Atferdsparadigmer (f.eks. hoderykningsrespons hos gnagere).<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Elektrofysiologi:<\/span><\/span><\/strong> \u00a0Effekter p\u00e5 nevrale oscillasjoner (f.eks. gammab\u00e5ndaktivitet).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    2. Biokjemiske og molekyl\u00e6re studier<\/span><\/span><\/strong><\/h4>\n
      \n
    • \n

      Intracellul\u00e6r signalering:<\/span><\/span><\/strong> \u00a0cAMP-akkumulering og \u03b2-arrestin-rekrutteringsanalyser.<\/span><\/span><\/p>\n<\/li>\n

    • \n

      Enzymkinetikk:<\/span><\/span><\/strong> \u00a0MAO-A-metabolisme (IC\u2085\u2080 ~2\u20135 \u03bcM).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      3. Klinisk relevant forskning<\/span><\/span><\/strong><\/h4>\n
        \n
      • \n

        Dose-respons-forhold:<\/span><\/span><\/strong> \u00a0Preklinisk sikkerhetsprofilering.<\/span><\/span><\/p>\n<\/li>\n

      • \n

        Sammenlignende farmakologi:<\/span><\/span><\/strong> \u00a0Mot psilocybin, DMT og andre tryptaminer.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        Eksperimentelle retningslinjer<\/span><\/span><\/strong><\/h3>\n

        Anbefalte konsentrasjoner<\/span><\/span><\/strong><\/h4>\n
        \n\n\n\n\n\n\n\n
        S\u00f8knad<\/span><\/span><\/strong><\/th>\nKonsentrasjonsomr\u00e5de<\/span><\/span><\/strong><\/th>\nL\u00f8semiddel<\/span><\/span><\/strong><\/th>\n<\/tr>\n<\/thead>\n
        Cellekulturer (in vitro)<\/span><\/span><\/td>\n1 nM \u2013 10 \u03bcM<\/span><\/span><\/td>\nPBS\/DMEM (\u22640,1% DMSO)<\/span><\/span><\/td>\n<\/tr>\n
        Reseptoranalyser<\/span><\/span><\/td>\n0,1\u2013100 \u03bcM<\/span><\/span><\/td>\nTris-HCl-buffer (pH 7,4)<\/span><\/span><\/td>\n<\/tr>\n
        Dyrestudier (ip\/iv)<\/span><\/span><\/td>\n0,1\u20135 mg\/kg<\/span><\/span><\/td>\nSteril saltl\u00f8sning<\/span><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

        Sikkerhetstiltak<\/span><\/span><\/strong><\/h4>\n
          \n
        • \n

          Personlig beskyttelse:<\/span><\/span><\/strong> \u00a0Laboratoriefrakk, hansker (nitril), vernebriller.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          H\u00e5ndtering:<\/span><\/span><\/strong> \u00a0Hygroskopisk \u2013 lukk umiddelbart etter bruk.<\/span><\/span><\/p>\n<\/li>\n

        • \n

          Lagring:<\/span><\/span><\/strong> \u00a0Lufttett, under argon, ved -20 \u00b0C (forhindre hydrolyse).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          Stabilitet og lagring<\/span><\/span><\/strong><\/h3>\n
            \n
          • \n

            Holdbarhet:<\/span><\/span><\/strong><\/p>\n

              \n
            • \n

              -20\u00b0C:<\/span><\/span><\/strong> \u00a0>2 \u00e5r (uendret renhet).<\/span><\/span><\/p>\n<\/li>\n

            • \n

              4\u00b0C:<\/span><\/span><\/strong> \u00a06 m\u00e5neder (i t\u00f8rt milj\u00f8).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

            • \n

              Nedrykk:<\/span><\/span><\/strong><\/p>\n

                \n
              • \n

                Hydrolyse ved langvarig eksponering for fuktighet (overv\u00e5ket med HPLC).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                \n

                Analytisk validering<\/span><\/span><\/strong><\/h3>\n

                Hvert parti leveres med:<\/span><\/span><\/p>\n

                  \n
                1. \n

                  HPLC-UV-kromatogram<\/span><\/span><\/strong> \u00a0(C18-kolonne, retensjonstid ~6,2 min).<\/span><\/span><\/p>\n<\/li>\n

                2. \n

                  MS\/MS-fragmentering<\/span><\/span><\/strong> \u00a0(karakteristiske ioner: m\/z 219 \u2192 174, 160).<\/span><\/span><\/p>\n<\/li>\n

                3. \n

                  Resterende l\u00f8semidler<\/span><\/span><\/strong> \u00a0(oppfyller ICH Q3C-retningslinjene).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                  \n

                  Juridisk status (Nederland\/EU)<\/span><\/span><\/strong><\/h3>\n
                    \n
                  • \n

                    Narkotikalovgivning:<\/span><\/span><\/strong> \u00a0Ikke eksplisitt nevnt i opiumsloven, men muligens under analog lovgivning (vedlegg II).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Vitenskapelig bruk:<\/span><\/span><\/strong> \u00a0Tillatelse kreves for institusjoner (CCMO-godkjenning for dyrefors\u00f8k).<\/span><\/span><\/p>\n<\/li>\n

                  • \n

                    Eksportkontroll:<\/span><\/span><\/strong> \u00a0Underlagt EU-forordning 2019\/1998 (psykotrope stoffer).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \n

                    Ofte stilte sp\u00f8rsm\u00e5l (FAQ)<\/span><\/span><\/strong><\/h3>\n

                    Q1 <\/span>Hva er fordelene med HCl fremfor fribase?<\/span><\/strong><\/span><\/p>\n

                      \n
                    • \n

                      Forbedret l\u00f8selighet<\/span><\/span><\/strong> \u00a0(ideelt for injeksjonsstudier).<\/span><\/span><\/p>\n<\/li>\n

                    • \n

                      Lengre hyllestabilitet<\/span><\/span><\/strong> \u00a0ved romtemperatur.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      Sp\u00f8rsm\u00e5l 2: Kan 5-MeO-DMT-HCl p\u00e5vises i narkotikatester?<\/span><\/span><\/strong>
                      \n A: Ja, via:<\/span><\/span><\/p>\n

                        \n
                      • \n

                        LC-MS\/MS<\/span><\/span><\/strong> \u00a0(gjenkjent som 5-MeO-DMT + HCl-addukt).<\/span><\/span><\/p>\n<\/li>\n

                      • \n

                        Immunoanalyser:<\/span><\/span><\/strong> \u00a0Kryssreaktivitet med DMT (~15-20%).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                        Sp\u00f8rsm\u00e5l 3: Er det noen risikoer ved kombinasjon med MAO-hemmere?<\/span><\/span><\/strong>
                        \n EN:\u00a0 <\/span><\/span>Absolutt.<\/span><\/span><\/strong><\/p>\n

                          \n
                        • \n

                          \u00d8kt risiko for\u00a0 <\/span><\/span>serotoninsyndrom<\/span><\/span><\/strong> \u00a0(unng\u00e5 kombinasjon!).<\/span><\/span><\/p>\n<\/li>\n

                        • \n

                          Brukes kun i MAO-frie modeller.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                          Q4: Hvordan skal man kvitte seg med avfall?<\/span><\/span><\/strong>
                          \n EN:<\/span><\/span><\/p>\n

                            \n
                          1. \n

                            N\u00f8ytraliser med\u00a0 <\/span><\/span>natriumbikarbonat<\/span><\/span><\/strong> \u00a0(pH 7\u20138).<\/span><\/span><\/p>\n<\/li>\n

                          2. \n

                            Adsorber med\u00a0 <\/span><\/span>aktivt kull<\/span><\/span><\/strong> .<\/span><\/span><\/p>\n<\/li>\n

                          3. \n

                            Kast som\u00a0 <\/span><\/span>farlig kjemisk avfall<\/span><\/span><\/strong> \u00a0(FN 3249, klasse 6.1).<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                            \n

                            Referanser og kontakt<\/span><\/span><\/strong><\/h3>\n

                            Kjernelitteratur:<\/span><\/span><\/strong><\/p>\n

                              \n
                            1. \n

                              Shen et al. (2010). \u00abFarmakologi av 5-MeO-DMT-derivater\u00bb.\u00a0 <\/span><\/span>J Psykofarmak<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n

                            2. \n

                              Kaasik et al. (2021). \u00abMetabolske veier for 5-MeO-DMT\u00bb.\u00a0 <\/span><\/span>Xenobiotika<\/span><\/span><\/em> .<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                              \n

                              Dette produktet er kun beregnet for autorisert vitenskapelig forskning. Ikke til konsum eller diagnostisk bruk. Vennligst f\u00f8lg lokale forskrifter.<\/span><\/span><\/em><\/p>","protected":false},"excerpt":{"rendered":"

                              5-MeO-DMT hydrochloride properties<\/span><\/span><\/span><\/h3>\n

                              Synonym:<\/span><\/span><\/strong> 5-methoxy-N,N-dimethyltryptamine hydrochloride <\/span><\/span>
                              \nCAS Number:<\/span><\/span><\/strong> n\/a <\/span><\/span>
                              \nFormula:<\/span><\/span><\/strong> 3-[2-(dimethylamino)ethyl]-5-methoxyindole hydrochloride <\/span><\/span>
                              \nMolar mass:<\/span><\/span><\/strong> 254.8 g\/mol <\/span><\/span>
                              \nPurity:<\/span><\/span><\/strong> >97%<\/span><\/span><\/p>\n","protected":false},"featured_media":28979,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[511,381],"product_tag":[326],"class_list":{"0":"post-23504","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-5-meo-dmt-kopen","7":"product_cat-tryptamines","8":"product_tag-nl","10":"first","11":"instock","12":"taxable","13":"shipping-taxable","14":"purchasable","15":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product\/23504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/comments?post=23504"}],"version-history":[{"count":6,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product\/23504\/revisions"}],"predecessor-version":[{"id":28467,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product\/23504\/revisions\/28467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/media\/28979"}],"wp:attachment":[{"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/media?parent=23504"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product_brand?post=23504"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product_cat?post=23504"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/researchchemicallab.eu\/nb\/wp-json\/wp\/v2\/product_tag?post=23504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}